Biest 50:50
A compounded estradiol-and-estriol option, prescribed when chosen with your clinician.
Best for: Hot flashes · Night sweats · Mood
Free shipping · Cancel anytime · HSA / FSA eligible · No membership fee
Biest 50:50 is a compounded preparation that combines two estrogens — estradiol and estriol — in equal parts, prepared by a licensed compounding pharmacy. We offer it as a personalization option for women who, with their clinician, choose a compounded approach. We lead with body-identical estradiol; compounded hormones are compounded individually by a state-licensed 503A pharmacy rather than mass-manufactured to a standardized, tested product, and we do not claim Biest is safer or more effective.
What it does
- Combines estradiol and estriol in a 50:50 ratio
- Compounded to your clinician's prescription by a licensed pharmacy
- A personalization option chosen together with your clinician
Biest delivers two forms of estrogen — estradiol, the most potent, and estriol, a weaker estrogen — to relieve estrogen-deficiency symptoms such as hot flashes and night sweats. Because it is compounded individually by a state-licensed 503A pharmacy rather than mass-manufactured to a standardized, tested product, this specific preparation is not reviewed for safety, efficacy, or dose consistency.
Your clinician prescribes the strength and a licensed pharmacy compounds it. As with all menopause care, the dose is guided by your symptoms rather than routine blood panels.
Menopause is diagnosed and titrated by how you feel. Routine bloodwork is not required — your clinician may suggest tests in specific situations, but they are optional, not a prerequisite for care.
Ingredients
- Estradiol (compounded)
- Estriol (compounded)
The price is the medication — the rest is included
- Free, discreet shipping
- Unlimited clinician messaging
- Automatic refills
- Cancel anytime — no lock-in
- No membership fee
- HSA / FSA eligible
What the guidelines support
ACOG
There is no evidence that compounded bioidentical hormones are safer or more effective than standard hormone therapy.
Where this fits in your care
Hot flashes & night sweats
Hot flashes and night sweats are the most common — and most treatable — symptoms of menopause. Hormone therapy is the most effective treatment available.
Mood & brain fog
Brain fog, irritability, and low mood are real, hormone-driven symptoms of the menopause transition — not personal failings.
Other options to consider
Many women combine therapies. Your clinician helps you choose the right plan.
Estradiol patches
Transdermal patch, applied twice weekly · Prescription
$159/mo
monthly or quarterly billing
Estradiol patch, applied twice weekly.
Estradiol tablets
Oral tablet, once daily · Prescription
$79/mo
monthly or quarterly billing
Oral estradiol for menopause symptoms.
Estradiol gel
Transdermal gel, applied daily · Prescription
$99/mo
monthly or quarterly billing
Transdermal estradiol gel, applied daily.
Questions, answered
No. Biest is a compounded combination of estradiol and estriol, prepared individually by a state-licensed 503A pharmacy rather than mass-manufactured to a standardized, tested product. We lead with body-identical estradiol and offer Biest as a personalization option chosen with your clinician.
Important: compounded medication
Biest is a compounded medication. Compounded hormones, including estriol, are compounded individually by a state-licensed 503A pharmacy rather than mass-manufactured to a standardized, tested product. We do not claim Biest is safer, more natural, or more effective than standard hormone therapy. A licensed clinician determines whether it is appropriate for you.
Feel like yourself again.
Take the 3-minute assessment, then meet your clinician by video or phone. No obligation.