Estradiol Patches
Estradiol patch, applied twice weekly.
Best for: Hot flashes · Night sweats · Sleep disruption
Free shipping · Cancel anytime · HSA / FSA eligible · No membership fee
A transdermal estradiol patch delivers a steady dose of estrogen through the skin — the form most guidelines favor for its lower clot risk versus oral estrogen. It is the most effective treatment available for vasomotor symptoms like hot flashes and night sweats. We offer the twice-weekly (biweekly) patch.
What it does
- Most effective treatment for hot flashes and night sweats
- Steady transdermal dosing, applied twice weekly
- Lower clot risk profile than oral estrogen
- Guideline-concordant
The patch releases 17β-estradiol — chemically identical to the estrogen your body made before menopause — through the skin and directly into the bloodstream, bypassing the liver. Steady levels calm the brain's temperature-regulation center, which is what drives hot flashes and night sweats.
We offer the twice-weekly patch in 0.025–0.1 mg/day strengths. Your clinician selects a starting dose and adjusts based on your symptoms — menopause is diagnosed and titrated by how you feel, not by routine blood panels. Available with monthly or quarterly billing.
Menopause is diagnosed and titrated by how you feel. Routine bloodwork is not required — your clinician may suggest tests in specific situations, but they are optional, not a prerequisite for care.
Ingredients
- 17β-estradiol
The price is the medication — the rest is included
- Free, discreet shipping
- Unlimited clinician messaging
- Automatic refills
- Cancel anytime — no lock-in
- No membership fee
- HSA / FSA eligible
What the guidelines support
The Menopause Society, 2023 Position Statement
Hormone therapy is the most effective treatment for vasomotor symptoms (hot flashes, night sweats).
ACOG
Transdermal estrogen may carry a lower risk of venous thromboembolism than oral estrogen.
Where this fits in your care
Hot flashes & night sweats
Hot flashes and night sweats are the most common — and most treatable — symptoms of menopause. Hormone therapy is the most effective treatment available.
Sleep disruption
Menopause disrupts sleep through night sweats, anxiety, and falling progesterone. Treating the hormonal cause restores rest in a way sleep aids cannot.
Mood & brain fog
Brain fog, irritability, and low mood are real, hormone-driven symptoms of the menopause transition — not personal failings.
Other options to consider
Many women combine therapies. Your clinician helps you choose the right plan.
Estradiol tablets
Oral tablet, once daily · Prescription
$79/mo
monthly or quarterly billing
Oral estradiol for menopause symptoms.
Estradiol gel
Transdermal gel, applied daily · Prescription
$99/mo
monthly or quarterly billing
Transdermal estradiol gel, applied daily.
Progesterone capsules
Oral capsule, at bedtime · Prescription
$59/mo
monthly or quarterly billing
Micronized progesterone for sleep and uterine protection.
Questions, answered
If you have a uterus, estrogen is paired with progesterone to protect the uterine lining. Your clinician will recommend the right combination during review.
Good to know
Hormone therapy has risks as well as benefits; a licensed clinician will review your history to determine whether it is appropriate for you.
Feel like yourself again.
Take the 3-minute assessment, then meet your clinician by video or phone. No obligation.